Lactose is the main source of sugar from milk and milk products from all mammals except the sea lion. Inadequate lactase activity allows lactose to reach the large intestine. There, the gut flora provides a salvage pathway for lactose digestion by cleaving lactose into short-chain fatty acids and gas, mainly hydrogen (H2), carbon dioxide (CO2), and methane (CH4). Non-digested lactose can cause osmotic diarrhoea; products of its bacterial digestion can lead to secretory diarrhoea and gas distending the intestines, events that are likely to lead to clinical symptoms. Lactose malabsorption actually refers to inefficient digestion of lactose due to reduced expression or impaired activity of the enzyme lactase. After ingestion, lactose passes into the small intestine where it comes into contact with lactase at the intestinal brush border where it is hydrolysed into the monosaccharides glucose and galactose, which can be readily absorbed. Dis accharide digestion occurs on the brush bord...
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